British PM David Cameron votes in Brexit referendum at polling station in London

Britain's Prime Minister David Cameron and his wife Samantha leave after voting in the EU referendum, at a polling station in central London on June 23, 2016. PHOTO: REUTERS

LONDON (AFP) - British Prime Minister David Cameron cast his vote on Thursday (June 23) in Britain's referendum on whether to remain in the European Union.

Mr Cameron, who has led the "Remain" campaign, went to a polling station in central London with wife Samantha to fill in his ballot, an AFP photographer at the scene saw.

Millions of Britons began voting on Thursday in a bitterly-fought, knife-edge referendum that could tear up the island nation's EU membership and spark the greatest emergency of the bloc's 60-year history.

A record 46.5 million voters were registered to decide Britain's future in the 28-nation European Union, which was born out of a determination to unite in lasting peace after the carnage of two world wars.

Across much of southeast England, many voters braved heavy rain and thunderstorms, which flooded some London streets, to reach polling stations. The once-in-a-generation referendum asks: "Should the United Kingdom remain a member of the European Union or leave the European Union?"

In one of the last opinion polls before the vote, "Remain" took a lead with 48 per cent, notably ahead of "Leave" on 42 per cent. The rest were undecided, said the telephone survey by ComRes for the Daily Mail and ITV News.

Two other polls published on the eve of the referendum - both conducted over the Internet - had put the "Leave" camp ahead by one or two percentage points, well within the margin of error.

World financial markets appeared to be banking on a "Remain" victory. In Tokyo trade, sterling briefly hit US$1.4844 - its highest level so far this year.

Financial institutions are reinforcing their trading teams to cope with the prospect of frantic trading through the day and the world's leading central banks say they are ready to react to any eventuality.

With no exit polls taking place, the result is unlikely to begin emerging before about 3am GMT on Friday.

Using the hashtag #ivoted, some people began posting mobile phone images of their filled-in ballot papers on Twitter. Election authorities had asked voters to refrain from taking selfies.

"Our polling station had a queue of people waiting to get in at 7am - first time anyone can remember that on polling day," voter Nick Turner in north-western Cumbria said on Twitter.

Under clear skies in Glasgow, Scotland, people were waiting to cast a ballot. "It would be silly to leave," the first voter Gemma Rosario, a 24-year-old office worker, told AFP. "Being in the EU is an advantage for Scotland."

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Scottish voters say the result of a referendum on European Union membership could spark a second Scottish independence vote.

The often acrimonious, deeply emotional campaign has exposed a gulf between Britons on the membership of Europe, with immigration and the economy the hot-button issues.

The Thursday editions of British newspapers captured the drama of voting day. "Independence day" was the headline of the pro-Brexit Sun, while The Times called it a "Day of reckoning".

Leading Brexit backer Boris Johnson, a former London mayor who is widely touted as a future prime minister, insisted the "Leave" campaign was on the brink of victory.

"I do think that we are on the verge, possibly, of an extraordinary event in the history of our country and indeed in the whole of Europe," Mr Johnson said in a final scramble for support on Wednesday.

Mr Cameron, who faces calls to resign if there is a "Leave" vote, implored people to stay in the bloc at his final rally. "Winston Churchill didn't give up on European democracy... and we shouldn't walk away," he said. "Our economy will suffer if we leave."

EU leaders have warned Britons that there would be no turning back from a vote to quit.

"Out is out," European Commission chief Jean-Claude Juncker said on Wednesday, dismissing any talk of a post-vote renegotiation of Britain's membership terms.

French President Francois Hollande warned an exit would be "irreversible".

A British withdrawal from the EU would trigger a lengthy exit negotiation, leading to the loss of unfettered access to its partners in the EU's single market and forcing the country to strike its own trade accords across the world.

In Europe, the referendum has raised concerns of a domino effect of exit votes that would imperil the integrity of the bloc, already buffeted by the euro zone and migration crises.

Though many voters fret over the financial consequences of a Brexit, others relish the prospect of taking back power from Brussels and reining in high levels of immigration.

EU leaders will open a two-day summit in Brussels on Tuesday to deal with the outcome and decide how to cope with the risk of similar referendums on the continent that could threaten the bloc's integrity.

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