LONDON (AFP) - Mauricio Pochettino admitted his Tottenham stars are suffering from fatigue after they lost for the first time at their new stadium as Michail Antonio fired West Ham to a surprise 1-0 victory on Saturday (April 27).
Pochettino's side had won all four matches at their new £1 billion (S$1.77 billion) Tottenham Hotspur Stadium.
But Antonio's clinical second-half strike ended that run as the West Ham winger became the first visiting player to score in the plush arena.
Third-placed Tottenham's second defeat in their last three Premier League games put a dent in their bid to finish in the top four.
They hold a three-point lead over fourth-placed Chelsea and are four points ahead of fifth-placed Arsenal, with both teams in action on Sunday.
It was a frustrating warm-up for Tottenham's Champions League semi-final first leg against Ajax Amsterdam in north London on Tuesday.
Blaming Tottenham's hectic fixture list for their defeat, Pochettino said: "We cannot put away the circumstance. They arrived fresh and ready to compete, for us it is completely different.
"We were tired. We knew that it was going to be tough because it was a derby, but we have to move on.
"It was really tough today. We did not manage the ball properly. In the second half we conceded a lot of space for them to counter attack."
Conceding that Tottenham had hurt their hopes of qualifying for next season's Champions League, Pochettino added: "It is a fight, it is a race, with two games to play. We knew that before."
Pochettino had insisted Tottenham's first European semi-final since the 1984 Uefa Cup was less significant than their top-four challenge.
But the Tottenham manager's team selection told a different story.
Defender Jan Vertonghen was absent with a reported injury as Pochettino made four changes, including resting Kieran Trippier, Victor Wanyama and Fernando Llorente.
Pochettino revealed this week that injured striker Harry Kane hopes to be fit for the Champions League final if Tottenham make it and the England captain was watching from the stands as his club's unbeaten start in the new stadium came to an end.
With Son Heung-min suspended for the Ajax first leg, Pochettino had no reason to rest the South Korea forward against the Hammers and he was swiftly into the action as he raced away for a shot that cleared the bar.
Son should have done better on that occasion and he fluffed his lines again with a low shot that was too close to Hammers keeper Lukasz Fabianski after Dele Alli's pass gave him a clear sight of goal.
A flowing Tottenham move unlocked the West Ham defence and Son's blocked effort dropped perfectly for Christian Eriksen, but the Dane smashed his close-range shot straight at Fabianski.
Tottenham found it tougher to maintain any momentum in the second half, with Son's unsuccessful penalty appeal, after being bundled over by Arthur Masuaku, made more in hope than expectation.
Manuel Pellegrini's team were growing in confidence and they ended Tottenham's unblemished record in their new arena in the 67th minute.
Marko Arnautovic chipped a superb pass towards Antonio and the winger controlled on his chest in the six-yard box before blasting a powerful finish past Hugo Lloris.
Celebrating with a bizarre bouncing motion, Antonio staged a joyous jig in front of the West Ham fans.
"The celebration is from a guy called Dan Rue on Instagram who does these crazy dance moves. I have been busting it out in the clubs and I thought I have to bring it on the pitch. I love to bring out a bit of personality out there," Antonio said of his eye-catching dance.
Tottenham looked drained in the closing stages, but they could have denied West Ham their first away win of 2019 when Vincent Janssen's stoppage-time header was cleared off the line by Fabian Balbuena.