WASHINGTON (AFP) - Hollywood megastar Angelina Jolie announced on Tuesday that she has had her ovaries and fallopian tubes removed over fears of a hereditary form of cancer, following her double mastectomy two years ago.
The actress, who has lost her mother, grandmother and aunt to the disease, said she had the procedure last week after results from a blood test raised fears that she may be in the early stages of cancer.
Although later tests showed that wasn't the case, Jolie said she chose to go ahead with the surgery because of her family history and because she carries a gene mutation that had given her a 50 per cent risk of developing ovarian cancer, the same mutation that put her at 87 per cent risk of developing breast cancer.
"I did not do this solely because I carry the BRCA1 gene mutation, and I want other women to hear this," Jolie wrote in an op-ed piece in The New York Times, the same way she announced her double mastectomy two years ago.
"A positive BRCA test does not mean a leap to surgery," said Jolie, who is married to fellow Hollywood heavyweight Brad Pitt.
"In my case, the Eastern and Western doctors I met agreed that surgery to remove my tubes and ovaries was the best option, because on top of the BRCA gene, three women in my family have died from cancer," she wrote.
Her doctors said that she should have the preventive surgery about a decade before the earliest onset of cancer in her female relatives.
"My mother's ovarian cancer was diagnosed when she was 49. I'm 39." Jolie said that she had been preparing for the possibility of ovary removal ever since her double mastectomy.
But two weeks ago, she said, she got a call from a doctor who said her blood test results had "a number of inflammatory markers that are elevated, and taken together they could be a sign of early cancer." She was told to see a surgeon immediately.
"I went through what I imagine thousands of other women have felt. I told myself to stay calm, to be strong, and that I had no reason to think I wouldn't live to see my children grow up and to meet my grandchildren," Jolie wrote.
"I called my husband in France, who was on a plane within hours. The beautiful thing about such moments in life is that there is so much clarity. You know what you live for and what matters. It is polarising, and it is peaceful."
She went to see a surgeon, the same one who had treated her mother and whom she last saw on the day that her mother died.
The examination and ultrasound were regular, so she waited for five days, saying she tried to stay calm and focused as she attended her children's football game and went about her daily life. Then scan results came back clean.
"To my relief, I still had the option of removing my ovaries and fallopian tubes and I chose to do it," she said.
The surgery has put the mother of six into menopause.
"I will not be able to have any more children, and I expect some physical changes. But I feel at ease with whatever will come, not because I am strong but because this is a part of life. It is nothing to be feared.
"It is not easy to make these decisions. But it is possible to take control and tackle head-on any health issue. You can seek advice, learn about the options and make choices that are right for you. Knowledge is power."