Opening tomorrow and running till May 29, the exhibition has a wide geographical reach.
It features treasures from ancient civilisations spanning Africa, Oceania and the Middle East, as well as Europe, Asia and the Americas.
On display are several iconic artefacts from the British Museum collection, including two 11th- century chess pieces discovered on the Hebridean Island of Lewis, skilfully crafted brass plaques from the West African state of Benin, ancient jewellery from the Royal Cemetery at Ur in southern Iraq and an exquisitely painted mummy board from ancient Egypt.
Taking The Straits Times on a tour, British museum curator Brendan Moore, 51, called the show "a very visceral experience".
Individually, each object "represents the cultural and artistic achievements of the civilisation it comes from", he says.
Collectively, they explore the enduring themes of life and death that connect people across the world.
On the significance of this show, Ms Jane Portal, keeper of the Department of Asia at the British Museum, highlights the ties between Singapore and Britain, which began with the arrival of Sir Stamford Raffles in 1819.
Although both museums have collaborated in the past, she calls the current partnership "unprecedented in its scale and ambition".
Objects from the Singapore collection are integrated into the show.
There is a section of artefacts from Raffles' personal collection, such as a Javanese mask and a kris and scabbard dating back to the early 19th century.
Two artworks from Singapore's national collection, Anthony Poon's W-White on 2P Waves and Iskandar Jalil's Blue Vessel, have also been included to juxtapose the nation's artistic development against global art movements in the 1980s.
Ms Angelita Teo, director of the National Museum of Singapore, calls the show "a timely reminder of the importance of the object in preserving Singapore's history, as well as a step towards the appreciation of the common values, aspirations and themes that connect us all".
The exhibition's biggest draws, no doubt, will be its exotic antiquities from around the world.
One of them is a mummy of an adolescent boy from Egypt, dating from between AD 100 and 120.
Inserted into the bandages over the face is a portrait of the subject, who was a young man with dark hair.
Another is an imposing bust of the Roman emperor Hadrian (ruled AD 117-138) found in his famous country residence near Tivoli.
Shown in the battle dress of a general, the bust evokes his role as the all-powerful commander-in- chief and imperial protector.
Exquisite ancient jewellery such as a string of beads with amulets said to be from Thebes, Egypt, masks and fabrics such as a gold death mask from Jerusalem and gold jewellery from ancient Mesopotamian graves, are a nod to the craftsmanship of times past.
Other noteworthy works appear on a must-not-be missed wall of artefacts that brings together different cultures and belief systems in the Indian sub-continent.
In one space, you get to see the Standing figure of Lord Buddha from ancient Gandhara in Pakistan, 16th century lion balustrades from India and a statue of the elephant god Ganesha from eastern India.
Ms Teo says: "In today's integrated world, to understand our own heritage and culture, we need to be exposed to other cultures, to better appreciate the world around us."
The exhibition also looks at how contemporary artists interpret their cultures and contexts in their artworks.
In Woman's Cloth (2001), Ghanian-born El Anatsui uses bottle tops and copper wire to create a large hanging canvas, a take on the Kente cloths, the native textiles of his homeland.
The discarded bottle tops come from several Nigerian liquor brands - a reference to Africa's colonial past. Alcohol was among the earliest things Europeans brought to Africa to exchange goods.
Pakistani artist Rashid Rana's arresting digital photomontage I Love Miniatures shows how art has evolved over time.
Tiny fragments of photographs of advertising billboards are used to create an image of the 17th-century Mughal emperor Shah Jahan (1569-1627), best remembered as the builder of the Taj Mahal in India.
Financial planner Mrunal Bharat Modak, 45, who plans to visit with her 12-year-old son during the school holidays, calls this "a fantastic opportunity" to understand the past.
"While our children read about ancient civilisations in textbooks, I feel they can remember, recall and understand things better when they have real encounters with artefacts.
"This is also a rare chance for all of us to see a part of the prestigious British Museum right here in Singapore," she says.
Editor Bridgette See, 40, who plans to visit with her eight-year-old son, says: "It will be like a whirlwind world tour with an impressive breadth of what the world has to offer, from past civilisations to the present."
•To watch British Museum curator Brendan Moore talk about the significance of this exhibition, go to str.sg/ZDsT
Special programmes
Treasures: A Journey Around The World by Brendan Moore, curator, department of international engagement, British Museum
What: Moore's lecture will consider how these objects have helped to shape the way we understand the past and present and prompt us to look at the enduring themes of life and death that connect people across cultures.
He has worked on a number of major international museum projects, including the development of the award-winning Enlightenment Gallery in the British Museum and two television series about the institution for Channel 4 and the BBC.
When: Tomorrow, 2 to 3pm
Where: The Salon, Level 1, National Museum of Singapore
Admission: $16 a person
Collectors Of Asia At The British Museum 1753-2015 by Jane Portal, keeper of the department of Asia, British Museum
What: Since its founding in 1753, the British Museum has collected and displayed works from across Asia, both old and new.
This talk introduces collectors who have contributed to the renowned Asian collection, helping the British Museum realise its mission to collect, research and display the various cultures of the world.
When: Sunday, 2 to 3pm
Where: The Salon, Level 1, National Museum of Singapore
Admission: $16 a person
Curator's Tour led by Szan Tan, senior curator, National Museum of Singapore
What: A curator with the National Museum of Singapore since 1997, Singaporean Tan walks visitors through this exhibition to tell fascinating back stories behind some of the exhibition highlights as well as the Asia and Singapore connections.
When: Dec 18 and Jan 15, 7.30 to 8.30pm
Where: Special Exhibition Galleries, Basement, National Museum of Singapore
Admission: $20 a person
Shades Of Grey I - A Basic Portrait Sketching Workshop by Singapore artist Tang Ling Nah
What: Taking reference from selected portraits from the Treasures Of the World exhibition, artist Tang introduces participants to the genre of portraiture and shows them the basics of sketching using pencil on paper.
Tang, who usually works with charcoal and paper, has presented several large-scale charcoal drawings in the past exploring monuments and the human body.
Best suited for visitors aged 16 years and above.
When: Jan 9, Feb 13, March 12 and April, 9. 30 to 5pm
Where: Special Exhibition Galleries, Basement, National Museum of Singapore
Admission: $40 a person (inclusive of materials)
A Charmed Life - Jewellery- Making Workshop by My Vintage Jewel Box
What: Learn how to make your own gold brass pendant using traditional jewellery-making techniques in this two-hour workshop which takes you though the full creation process - from designing on paper to fashioning a finished product.
The workshop will be led by Ryn Tang, a Singaporean artist who has been crafting jewellery since 2009.
Best suited for visitors aged 13 years and above.
When: March 26, April 30, 3 to 5pm
Where: Seminar Rooms, Level 2, National Museum of Singapore
Admission: $52 a person
• Tickets are available from Sistic (www.sistic.com.sg). Prices do not include admission to the exhibition. For more details, call 6332-3659 or 6332-5642
Exhibition highlights