It's not just Scottish seccession that Britain needs to worry about.
A petition for London to leave Britain and join the European Union has picked up more than 95,000 signatures.
Petition organiser James O'Malley says in his entreaty to Londoners on Change.org: "London is an international city, and we want to remain at the heart of Europe."
He hashtagged his petition #londependence, and appealed to London mayor Sadiq Khan: "Wouldn't you prefer to be President Sadiq?".
Nearly 60 per cent of people in the capital backed the Remain campaign, said the BBC.
Mr O'Malley told the BBC he was "astonished" the petition had taken off but suggested it showed he had "clearly touched a nerve" with others who "like me want to live in an international city".
One supporter of the petition posted arguments for London's independence that parody those voiced by the leave camp.
"London has *no control* over its borders while it remains a member of the UK. Since 2007, there have been more people coming into London from the UK than there have from the rest of the world combined," the supporter John Gowers said.
Mr Sadiq asked for calm in response to the referendum result, and said that he will push for Britain to remain within the single market.
"I still believe that our country is better off within the European Union, but there is no doubt that London will continue to be the successful city it is today," he said.
He also addressed Europeans living in London, who he said "make a huge contribution to our city".
"You are welcome here. We value the enormous contribution you make to our city and that will not change as a result of this referendum," he said.