NEW YORK (NYTIMES) - Federal health officials have now confirmed 28 cases, including six in men, of a rare blood-clotting disorder in adults who have received the Johnson & Johnson Covid-19 vaccine.

Dr Tom Shimabukuro, the deputy director of the immunisation safety office at the Centres for Disease Control and Prevention (CDC), presented the new cases on Wednesday (May 12) at a meeting of a panel of advisers to the CDC.

The figure is an increase from the 15 confirmed cases, all of which were in women, that were reported at last month's meeting.

Although officials have now identified a handful of cases in men, women - especially those between the ages of 30 and 49 - appear to remain at elevated risk.

"The trend is that the reporting rates are higher in females compared with males in all age categories," Dr Shimabukuro said at the meeting.

Patients with the rare but serious disorder develop both blood clots, often in the brain, and low levels of platelets, blood components that promote clotting. The disorder is a "rare, clinically serious and potentially life-threatening condition", Dr Shimabukuro said.

Last month, after reports first emerged that six women who had received the vaccine had developed the disorder, federal health officials recommended pausing use of the vaccine while they investigated.

They lifted the suspension 10 days later and added a warning about the potential risks to the vaccine's label, which notes that a connection between the vaccine and the condition is "plausible".

Twenty-two of the confirmed cases so far have been in women, and six have been in men. All were in adults between the ages of 18 and 59 who received the vaccine before the national pause. (There was also one additional case recorded in a 25-year-old man who participated in the clinical trial.)

Three people have died and four remain hospitalised, including one who is in intensive care. No new deaths have been documented since last month's meeting, Dr Shimabukuro said.

The overall risk remains exceedingly low. More than nine million doses of the Johnson & Johnson vaccine have now been administered in the United States.

There have been 12.4 cases per million doses among women between the ages of 30 and 39 and 9.4 cases per million doses among women between 40 and 49, the two demographic groups that appear to be at highest risk. Among older women and men of all ages, there were fewer than three cases per million doses.

Among the 28 confirmed cases, 12 people who developed the disorder had obesity, seven had high blood pressure, three had diabetes, and three were taking oestrogen, although it is not yet clear whether any of those factors might substantially increase the risk of the disorder.

Officials will continue to monitor for cases of the clotting disorder in people who have been vaccinated, Dr Shimabukuro said.

There have been no confirmed cases of the clotting disorder following the Pfizer-BioNTech or Moderna vaccines, which employ a different technology, Dr Shimabukuro said.