Growth has been somewhat uneven, and there are still blighted neighbourhoods as in many other American cities. But from 2010 to 2015, overall employment grew by 4.3 per cent, and relative poverty declined. Ageing remains an issue although a once-precipitous decline in the city's population has slowed.
"Pittsburgh was a leader in bottoming out as it were," Ms Audrey Russo, president and CEO of the Pittsburgh Technology Council, a tech industry association with over 1,300 members, tells The Straits Times.
"Then a significant but loosely affiliated leadership that represented CMU, advanced manufacturing, and some of the research that came out of the University of Pittsburgh Medical Centre began to weave themselves together.
"The other variable was philanthropy; Pittsburgh has the second-highest pool of philanthropic money in the US. It plugged a huge hole and invested in the arts, in education, in some of the neighbourhoods," she says.
The multiplier effect of the synergy between universities and the private sector is evident. One of the co-founders of HiberSense is the former chair of computer science at the University of Pittsburgh, Professor Daniel Mosse. The NREC spins off companies to commercialise its technology; Astrobotic is one such spin-off.
PEOPLE PROBLEM
However, the NREC is concerned about human resources, says its director, Dr Herman Herman.
There is a shortage not just of engineers but also of technicians, says the Indonesia-born Dr Herman, who is in his 40s.
He came to Pittburgh in 1986 and got his PhD in robotics from CMU.
"We're trying to educate more engineers and technicians because there are plenty of positions. Some of these skill sets don't require a PhD."
He adds: "Robotics, if you take related industries, already employs easily tens of thousands. Like today's auto industry, robotics will employ millions. Think of it - you will need support to service the robot you have in your house."
"This is about the evolution of technology. People have to catch up with it."