Singapore's Ministry of Foreign Affairs said on Wednesday that the Republic was "deeply concerned" about recent events in Jerusalem, a day after an attack at a synagogue in the city left seven dead.

"Singapore is deeply concerned about recent developments in Jerusalem. We condemn all acts of violence against innocent civilians, in particular the heinous attack at a synagogue on 18 November 2014," an MFA spokeman said in a statement.

"Places of worship of all faiths are sacrosanct and must be respected and protected by all. We call on the political leadership on all sides to avoid escalating tensions which could spiral into a new cycle of violence," the official said.

Two Palestinians wielding a gun and meat cleavers killed five Israelis at a Jerusalem synagogue on Tuesday, in the city's bloodiest attack in six years. The assailants later died in a gun fight with police.