LONDON (AP) - More than a decade ago, British parents refused to give measles shots to at least a million children because of a vaccine scare that raised the spectre of autism. Now, health officials are scrambling to catch up and stop a growing epidemic of the contagious disease.
This year, Britain has had more than 1,200 cases of measles, after a record number of nearly 2,000 cases last year. The country once recorded only several dozen cases every year. It now ranks second in Europe, behind only Romania.
Last month, emergency vaccination clinics were held every weekend in Wales, the epicentre of the outbreak. Immunisation drives have also started elsewhere in the country, with officials aiming to reach one million children aged 10 to 16.
"This is the legacy of the Wakefield scare," said Dr David Elliman, spokesman for the Royal College of Paediatrics and Child Health, referring to a paper published in 1998 by Dr Andrew Wakefield and colleagues.
That work suggested a link between autism and the combined childhood vaccine for measles, mumps and rubella, called the MMR. Several large scientific studies failed to find any connection, the theory was rejected by at least a dozen major British medical groups, and the paper was eventually retracted by the journal that published it.
Still, MMR immunisation rates plummeted across Britain as fearful parents abandoned the vaccine - from rates of over 90 per cent to 54 per cent.
Nearly 15 years later, the rumours over MMR are still having an impact. Now there's "this group of older children who have never been immunised who are a large pool of infections", Dr Elliman said.
The majority of those getting sick in Britain - including a significant number of older children and teens - had never been vaccinated. Almost 20 of the more than 100 seriously ill children have been hospitalised and 15 have suffered complications including pneumonia and meningitis. One adult with measles has died, though it is unclear if it was the disease that killed him.
The first measles vaccines were introduced in the 1960s, which dramatically cut cases of the rash-causing illness. Since 2001, measles deaths have dropped by about 70 percent worldwide; Cambodia recently marked more than a year without a single case.
Globally, though, measles is still one of the leading causes of death in children under five and kills more than 150,000 people every year, mostly in developing countries. Measles is highly contagious and is spread by coughing, sneezing and close personal contact with infected people; symptoms include a fever, cough, and a rash on the face.
Across Britain, about 90 per cent of children under 5 are vaccinated against measles and have received the necessary two doses of the vaccine. But among children now aged 10 to 16, the vaccination rate is slightly below 50 per cent in some regions.
To stop measles outbreaks, more than 95 per cent of children need to be fully immunised. In some parts of Britain, the rate is still below 80 per cent.
Unlike in the United States, where most states require children to be vaccinated against measles before starting school, no such regulations exist in Britain. Parents are advised to have their children immunised, but Britain's Department of Health said it had no plans to consider introducing mandatory vaccination.
Last year, there were 55 reported cases of measles in the US, where the measles vaccination rate is above 90 per cent. So far this year, there have been 22 cases, including three that were traced to Britain. In previous years, Britain has sometimes exported more cases of measles to the US than some countries in Africa.
Ms Portia Ncube, a health worker at an East London clinic, said the struggle to convince parents to get the MMR shot is being helped by the measles epidemic in Wales.
"They see what's happening in Wales so some of them are now sensible enough to come in and get their children vaccinated," she said.
Clinic patient Ellen Christensen, mother of an infant son, acknowledged she had previously had some "irrational qualms" about the MMR vaccine.
"But after reading more about it, I know now that immunisation is not only good for your own child, it's good for everyone," she said.