England's two most successful clubs will come head to head at Anfield on Monday (Tuesday morning, Oct 18, Singapore time), with Jurgen Klopp keen to avenge Manchester United's English Premier League double over Liverpool last season.
Here's a look at the key battles that will define this big match.
1. Jordan Henderson v Paul Pogba
The Liverpool captain is in arguably the best form of his career - He has had the most touches (711) and most passes (589) not only for Liverpool this season, but in the whole of the EPL, as he dictates play in the middle. Pogba plays a similar key role in midfield for United, creating 11 chances for his team-mates so far although he has yet to record an assist.
2. Loris Karius v Zlatan Ibrahimovic
Liverpool have yet to keep a clean sheet in the league this season but goalkeeper Karius is expected to keep his place, despite Simon Mignolet pressing hard to reclaim the No. 1 spot. The big test for Karius is to keep the world-class Ibrahimovic, United's top scorer this term with six goals in all competitions, quiet.
3. Sadio Mane v David de Gea
New boy Mane's dynamic and speedy forward play has brought a sense of excitement and optimism to Liverpool, with three goals and three assists. He will be up against a top-class goalkeeper in de Gea, who is remembered at Anfield last season for making crucial saves either side of the halves before Wayne Rooney scored the winner in a 1-0 victory.
4. Philippe Coutinho v Eric Bailly
Coutinho was impressive for Liverpool in their last league game as they came from behind to beat Swansea 2-1. The Brazilian maestro will be key as he can find pockets of space to spread panic in defences. His brilliant solo goal in the Europa League against the Red Devils is still fresh in the memories of both sets of supporters. But it will not be easy against Bailly, who has been rock solid in the heart of United's defence, picking up multiple Man-of-the-Match awards since his move from Villarreal in the summer.
5. Jurgen Klopp v Jose Mourinho
This is the first time the two big-personality managers face off as the managers of Liverpool and United. They clashed on five previous occasions (four times for Borussia Dortmund vs Real Madrid and once for Liverpool vs Chelsea) with Klopp winning thrice and drawing once. The German's high-pressing style of play will be a threat to United, who have had slow build-ups to their game this campaign. However, Mourinho's side have shown that they too can conjure up a fast-paced attack, notably in their last two matches against Stoke City and Leicester City.