Four years after routing Italy 4-0 to win the Euro 2012 title, Spain meet them again in the last 16 of Euro 2016 today.
Here are five classic Italy-Spain clashes.
Italy 2 Spain 1
World Cup 1994 quarter-finals
It was an 88th-minute Roberto Baggio winner that helped the Azzurri overcome a stubborn Spanish side in a lively quarter-final in Boston.
Dino Baggio's 25-metre piledriver gave Arrigo Sacchi's men a 25th-minute lead, only for Jose Luis Caminero to level on the hour.
Spain were livid when Mauro Tassotti's vicious elbow that left now Barcelona coach Luis Enrique bloodied and prone in the penalty area went unpunished, before Baggio ran on to a cross to round Andoni Zubizarreta and beat the Spanish legend with a crisp finish from a tight angle.
Spain 0 Italy 0
(Spain win 4-2 on penalties)
Euro 2008 quarter-finals
Spain goalkeeper Iker Casillas was the hero for Luis Aragones' men as Italy maintained their tradition of coming up short from the penalty spot.
In the shoot-out, Casillas saved from Daniele de Rossi and Antonio di Natale.
Cesc Fabregas then made no mistake against Gianluigi Buffon to send Spain into the semis and on their way to ending a 44-wait to be crowned kings of Europe.
Spain 1 Italy 1
Euro 2012 group stage
Although still at the group stage, this was an eagerly awaited fixture between a desperate Italy side and the defending champions.
Italy were given a 61st-minute lead in Gdansk by di Natale.
But a slick Spain rescued a share of the spoils shortly after, when Fabregas finished off a move of lightning-quick passes from Andres Iniesta and David Silva to fire past Buffon.
Spain 4 Italy 0
Euro 2012 final
Making amends for their 1-1 draw with Italy in the group stage, Silva, with a rare header, and Jordi Alba, scoring his first Spain goal, gave Vicente del Bosque's men a two-goal lead at the break.
Italy struggled to respond and Fernando Torres and Juan Mata added two more Spain goals inside the final six minutes to hand La Roja an unprecedented hat-trick of major tournament wins.
Spain 0 Italy 0
(Spain win 7-6 on penalties)
Confederations Cup 2013 semi-finals
In the searing heat of Fortaleza in Brazil, neither side could find the breakthrough in regulation time.
Italy midfielder Emanuele Giaccherini hit the post, while at the other end, Buffon tipped Xavi Hernandez's long-range effort onto the woodwork.
It went to penalties, and for a while, it seemed that even the spot kicks could not separate either side, as both hit the net six times apiece before Italian defender Leonardo Bonucci blasted over.
Jesus Navas stepped up to beat Buffon and send Spain into the final, where they succumbed 0-3 to Brazil.