After four years, Mr Koh Ming Hao lost his battle with cancer last week, barely a year after marrying his long-time sweetheart.
He died on Thursday, just a day after his 34th birthday, according to Shin Min Daily News.
Mr Koh, formerly a manager at Microsoft, had shared his arduous journey on Facebook.
He was diagnosed with terminal stomach cancer in June 2013 and given only a year to live.
But Mr Koh, known to friends as Ming, beat the odds and survived for four years.
"Hi everyone, am heartbroken to inform everyone that Ming has ended his journey peacefully at midnight... thank you for all the love and support through his toughest journey," said a post on his Facebook page on Friday.
"Till we meet again, babe" was the message his wife Daphnie Chong, also 34, left on her Facebook page.
Ms Chong told Shin Min that she and Mr Koh started dating when they were 15 years old. They were devastated when he was diagnosed with cancer.
"I thank heaven he was not taken away a year later, but lived three more years. From that time on, we were determined to live every day to the fullest," she said.
They held their wedding on Aug 20 last year. "I couldn't leave when he was at his lowest... I wanted to be with him every day for the remainder of his days," she said.
In his battle with cancer, Mr Koh underwent numerous operations and more than 60 chemotherapy treatments.
He lost weight but continued to work, travel and exercise.
Mr Koh's condition took a turn for the worse last month, while still undergoing chemotherapy.
"He will always be in my heart. He will always be the best boyfriend and best husband to me," Ms Chong added.
Through the Facebook page Watch Ming Beat Cancer, Mr Koh met other cancer patients. He shared his experiences, helped and encouraged them, his mother told Shin Min. The Facebook page is no longer available online.