Foreign Minister Vivian Balakrishnan met US Secretary of State Mike Pompeo on Tuesday, and the two men had a working lunch at the US State Department in Washington.
Dr Balakrishnan also met National Security Adviser John Bolton at the White House in the afternoon, Singapore's Ministry of Foreign Affairs said.
At both meetings, the two sides reaffirmed the excellent and longstanding ties between Singapore and the US.
Mr Pompeo and Mr Bolton expressed support for Singapore's chairmanship of Asean this year, and discussed ways in which the US could deepen its strategic and economic interests in the region.
Mr Pompeo and Mr Bolton also expressed appreciation for Singapore's hosting of the historic summit next week.