"This regulation becomes abnormal in obese people. Even if this set point is abnormally high, the body defends itself."
Bariatric surgery, or weight loss surgery, can "reset that set point", says Dr Shabbir, who is also president of the Obesity & Metabolic Surgery Society of Singapore.
As Singapore faces challenges such as obesity and related diseases such as diabetes, bariatric or metabolic surgery, which can swiftly address both conditions, is gaining popularity in some hospitals here.
Over the last five years, Singapore General Hospital (SGH) has seen a 10 per cent increase year-on-year in the number of patients undergoing bariatric surgeries. More than 700 patients have gone for such procedures there since 2008.
At National University Hospital, the number of bariatric surgeries performed rose from five in 2008 to 93 in 2015.
Dr Lim Chin Hong, consultant at SGH's department of upper gastrointestinal and bariatric surgery, attributes the rise in bariatric surgery at the hospital to greater awareness of its efficacy.
Research shows that bariatric surgery is more effective for long-term weight loss compared with dietary modifications or exercise, says Dr Lim, who will be speaking at a public forum on the topic later this month.
Trials have also shown it to improve or resolve conditions such as diabetes, hypertension, high cholesterol, sleep apnea and fertility, he adds.
"Most patients who are overweight and make exercise and dietary modifications tend to have a high rate of failure and relapse. Surgery not only restricts food intake, but also changes gut hormones that promote satiety; suppresses hunger and increases metabolism," he says.
"This is why metabolic complications like diabetes and hypertension improve immediately after surgery, even before the patient has lost significant weight."
That is not to say that those who are overweight should give up on exercise or dieting altogether.
Two common types of bariatric surgery are vertical sleeve gastrectomy, or gastric sleeve, which involves removing a portion of the stomach; and Roux-en-Y gastric bypass surgery, a more complex procedure where a small pouch is created from the stomach. The operation creates a connection from the stomach to the small intestine, bypassing portions of the digestive tract.
In Singapore, bariatric surgery is generally considered only for patients with a body mass index (BMI) - weight in kilograms divided by the square of one's height in metres - of above 32.5 if they have obesity-related illnesses such as diabetes, or a BMI beyond 37.5 if they do not.
One is considered severely obese with a BMI of 35.
In Singapore, 8.6 per cent of adults aged 18 to 69 were obese in 2013, Ministry of Health figures show. But Singapore could hit obesity rates of 15 per cent in just seven years, according to Health Promotion Board estimates reported earlier this year.
Globally, one in eight adults is obese, according to a major study published last year in The Lancet medical journal, and bariatric surgery is becoming one of the fastest-growing operative procedures, the Clinics In Surgery journal reported last year.
While some previously obese food lovers express frustration at having to eat much less after undergoing bariatric surgery, they often speak of the procedure with the fervour of the converted.
Some bariatric patients interviewed by The Sunday Times lost 60kg to 70kg post-surgery; some no longer take diabetes medication.
But bariatric surgery is not a magic bullet, caution doctors.
Dr June Lee, consultant of surgery at Changi General Hospital, says: "A patient may revert to his original weight and health issues, including diabetes, depending on factors such as maladaptive eating habits, lack of exercise, his age, or the duration and severity of his diabetes before the surgery."
But with proper self-care, NUH's Dr Shabbir says the physical effects of the surgery can be accompanied by a better quality of life.
She lost 30kg