1958: Born in Bay City, Michigan.
1977: At age 19, moves to New York City to pursue a dance career.
1983: Self-titled debut album peaks at No. 8 on the American charts and No. 6 in Britain. It contains Holiday, her first Top 40 hit song. Her distinctive style - bleached hair, lace and fishnet stockings and multiple accessories, including crucifixes - sparks a worldwide trend.
1984: Like A Virgin is her first No. 1 hit on the American album charts and triggers protests by organisations that accuse her of promoting pre-marital sex.
1985: Her first starring role in the comedy, Desperately Seeking Susan, becomes a box-office hit. Marries actor Sean Penn in August. They divorce in 1989.
1986: Third album True Blue is No. 1 around the world.
1989: The title track from her fourth album, Like A Prayer, attracts condemnation, including from the Vatican, for blending sex and religion. Both the song and album reach No. 1 worldwide.
1990: The Immaculate Collection, a compilation of her hits and new singles, is released and becomes the best-selling compilation of all time by a solo artist.
1991: Her first documentary film, Truth Or Dare, chronicles her successful Blond Ambition World Tour. Acclaimed by critics, it rakes in US$29 million at the box office - the biggest taking for a documentary film at that time.
1992: Stars in baseball drama A League Of Their Own and releases This Used To Be My Playground, the movie's theme song, which becomes a No. 1 hit.
Releases an explicit book, Sex, as well as her fifth album, Erotica. Appears in two films, Body Of Evidence and Dangerous Game.
1993: The Girlie Show World Tour is banned in Singapore on "moral and religious grounds".
1994: Bedtime Stories, her sixth album, tones down the sexual excess of her recent works and includes the R&B-influenced ballad Take A Bow, a No. 1 hit.
1996: Gives birth to her daughter, Lourdes Maria Ciccone Leon, whose father is fitness trainer Carlos Leon.
Stars as Argentinian First Lady Eva Peron in the film version of the Andrew Lloyd Webber stage musical, Evita, for which she earns a Golden Globe for Best Actress (Musical Or Comedy).
1997: You Must Love Me, her single from the soundtrack,wins an Academy Award for Best Original Song.
1998: Releases seventh album Ray Of Light, a critically acclaimed and commercially successful blend of electronica and pop that earns four Grammys, including for Best Pop Album.
2000: Music, her eight album, becomes her first since Like A Prayer to hit No. 1 on the American album charts.
Gives birth to her second child, a son, Rocco John Ritchie, with British film-maker Guy Ritchie. The couple wed later in the year.
2003: American Life, her ninth album, receives mixed reviews.
Kisses pop stars Britney Spears and Christina Aguilera in a performance at the 2003 MTV Video Music Awards.
First children's book, The English Roses, tops The New York Times' bestseller list.
2005: Her 10th album, Confessions On A Dance Floor, marks a return to dance-oriented pop and goes to No. 1 worldwide.
It also wins a Grammy Award for Best Electronic/Dance Album.
2006: Travels to Malawi for aid work and adopts a boy, David Banda.
2008: Billboard recognises her as the most successful solo artist in US chart history based on her No. 1 singles and albums. She is second overall only to The Beatles. In the same year, she is inducted into the Rock and Roll Hall of Fame and releases her 11th album, Hard Candy. Her marriage to Ritchie ends later in the year.
2009: The Supreme Court of Malawi approves the adoption of her second child from the country, Chifundo "Mercy" James, after an appeal.
2012: Her Super Bowl performance draws a then-record number of 114 million viewers, more than the game itself.
Releases her 12th album, MDNA, another No. 1 album on the American and British charts.
2014: With more than 300 million albums sold throughout her career, Guinness World Records recognises her as the best-selling female recording artist of all time.
2015: Releases her 13th album, Rebel Heart, which features collaborations with contemporary stars such as Avicii, Diplo and Kanye West. It peaks at No. 2 on American and British charts, but goes to No. 1 in several European countries.
2016: Set to perform in Singapore for the first time, on Sunday as part of the Rebel Heart Tour, her 10th global tour.
Eddino Abdul Hadi