He is so well-known that people forget the reasons for his fame. Could it be his 18 Grammy Awards for either solo or ensemble albums, many bafflingly out of the box?
His first Grammy was for a 1986 recording of Brahms' Cello and Piano Sonatas in E Minor and F.
In 2013, he received one for Best Folk Album with the bluegrassflavoured album, The Goat Rodeo Sessions, recorded with bassist Edgar Meyer, mandolin player Chris Thile and multi-instrumentalist Stuart Duncan.
Could it be his nice-guy personality? He cracks jokes backstage and sees concerts as "this big party we've invited the audience to". "You can't welcome people with a frown," he says.
Even those outside the concert- going circle might remember his appearances on children's television shows, Mister Rogers' Neighbourhood and Sesame Street, in the 1980s.
His polite, sunny manner perfectly matched those of Mr Rogers and Elmo. He himself had two young children then - a son and a daughter, now grown - with his wife, arts consultant Jill Hornor, who is one of the directors of the Silk Road Ensemble.
Ma's charm shines during a 30-minute phone call, a third of which he spends apologising for the 3.30am Singapore time slot.
He is astonishingly humble and admits to practising every day "to locate that state of mind necessary for music to exist".
"Part of homeostasis for a musician is to try and make sure that you have enough technique to transcend it and focus on the sound and content," he says, using the biological term for a state of equilibrium.
"There's the athleticism part of music-making which is neuromuscular control," he adds.
"An athlete also has to warm up and go through training to do a specific task."
Born in Paris, Ma grew up in the US because his parents moved there when he was seven years old.
His mother was a singer and his father a musicologist who failed to pique Ma's interest in the violin or piano.
Bigger instruments such as the double bass caught his eye - he has famously said the smaller cello was a compromise.
He started performing at age five and gave concerts before Dwight Eisenhower and John F. Kennedy - two of eight American presidents he has performed for.
Before he turned 10, he performed on television with his older sister, who plays the violin and is also a medical doctor.
Ma studied at Juilliard and graduated from Harvard, where his studies included archaeology and anthropology. He believes in the intersection of science and the arts - or rather, that philosophy, arts, sciences and the humanities are all necessary to help make sense of life.
For him, music is meant to have social impact.
"Having started music at a very young age, I've always asked myself, 'I love music, but what is it for?'
"We're not doing it because it pleases me, though that's part of it. Music heals people and it brings people to a biological state of equilibrium that allows people to function."
Hence the Silk Road Ensemble works with students at Harvard and trains teachers, including those from inner-city American schools where the first concern is to create a safe environment to help a child develop.
Ma himself is a United Nations Messenger of Peace and a member of the American President's Committee on the Arts & the Humanities.
He likes Singapore's peacefully multicultural environment, praising it for "focusing on constructive values".
He has played here several times. In 1993, he had a sold-out show at Victoria Concert Hall with British classical pianist Kathryn Stott.
He made his Singapore Symphony Orchestra debut under founder Choo Hoey's baton in 1995 and under current music director Shui Lan four years later, when he premiered Bright Sheng's Spring Dreams and also played the Elgar Cello Concerto.
He was a featured guest during the orchestra's 2005 tour of the US. He brought the Silk Road Ensemble to the Esplanade Concert Hall in 2010 as part of its 10th anniversary tour.
He says music and a multicultural group such as the Silk Road Ensemble can make a difference in times of increasing change and rising xenophobia.
"The world is changing at an alarming rate and that makes people afraid. Fear is the enemy of society, so we ask the question, 'What would be the antidote here? Is it trust, is it community, is it joy? What would be the most appropriate way to push back the darkness?'"
Art for art's sake is a relatively new idea, he says.
"Throughout classical music history, people wrote because a patron asked for music, or they wrote for the church or the community, to bring people together. Music is for life's sake."