Huge golden fans and black lacquer screens line the long hall that is restaurant Yellow Pot.
Helmed by chef Sebastian Goh, it delivers modern Chinese cooking - from delectable lion's mane mushrooms with avocado puree to the clean flavours of barramundi in housemade fish stock. A la carte breakfast is also served here in the mornings - the chilli crab omelette is especially recommended.
The luminous Anouska's Bar, named for its glamorous designer, serves classic cocktails with a Chinese twist - such as the Chen Pi Collins, a Tom Collins with mandarin-infused gin; or the Duxton Mary, a Bloody Mary laced with orange and hua diao wine.
Elsewhere in the hotel, eclectic elements pop up around each corner - from the old-school telephones in the corridors to the wallpaper, based on 18th-century English property indenture documents.
Historic shophouses give one little wiggle room, but the elegant screens and dark curves of Ms Hempel's design grant narrow spaces an intimate mystique.
My duplex suite is furnished with a small forest of standing lamps and a spiral staircase that leads up to the loft bed.
I am delighted because I love spiral staircases. If you are, however, the sort who hates tramping up and down steps to get your phone charger or switch off the said standing lamps before bed, opt for a basic Shophouse Room or the Montgomerie Executive Club Suite which, at 51 sq m, is the largest room.
I while away the afternoon wandering Duxton, a district once rife with KTV bars and ladies of the night that has regentrified in the past decade.
Today, upmarket boutiques and eateries sit cheek by jowl with the likes of the 124-year-old Say Tian Hng Buddha Shop, which makes Taoist effigies.
Duxton Reserve is within walking distance of two lovely independent bookstores - Littered With Books across the street and Chinese-language stalwart Grassroots Book Room in Bukit Pasoh Road.
A few doors down from the hotel is bespoke perfumery Maison 21G, which created the hotel's signature scent La Reserve - an enchanting potpourri of amber, oud, patchouli and a dash of ginger.
I pop in for a workshop with founder Johanna Monange, 45, who leads me through a dizzying spectrum of scents - from refreshing sage to the jaw-droppingly expensive orris, which is made from iris rhizomes that are dried over years and which can fetch more than €50,000 (S$80,750) a kilogram.
As I watch, she mixes up a bottle of La Reserve in Maison 21G's in-house machine La Source, something like an espresso machine, only with perfume cartridges.
The scent of it lingers long after I have unpacked back home. Duxton Reserve certainly knows how to leave an impression.
'Hospi-tel' with access to culturally rich neighbourhood
When describing my stay at One Farrer Hotel to friends, I found myself mixing up the words "hotel" and "hospital" very often.
Perhaps it is the five-star hotel's location - right next to Farrer Park Hospital, to which it is affiliated. Hospital experts were also consulted in the recently completed $2 million refurbishment of 70 per cent of the hotel - or 176 rooms - that fall under the Mint category of rooms at One Farrer.
Or perhaps it is the quiet, hospital-like hallways that lead to my Skyline room on the 19th floor, which overlooks the bustling Farrer Park neighbourhood.
In the pursuit of cleanliness, no detail has been spared. Carpets, which are a hotbed for germs and pathogens, have been removed from all Mint category rooms and common areas in favour of vinyl flooring for ease of cleaning.