Actress Christina Applegate says she was misdiagnosed with MS

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FILE Ñ Christina Applegate in New York, April 30, 2019. Applegate, who received a multiple sclerosis diagnosis in 2021, said on Tuesday, October. 20, 2026, that she had been unexpectedly plunged back into uncertainty after a doctor told her she didnÕt have multiple sclerosis, after all. (Tawni Bannister/The New York Times)

Christina Applegate (pictured here in 2019) said in her podcast on Oct 20 she was "not happy" at being misdiagnosed with multiple sclerosis.

PHOTO: TAWNI BANNISTER/NYTIMES

  • Christina Applegate said doctors misdiagnosed her with multiple sclerosis since 2021, leaving her with ongoing severe symptoms and feeling “back at square one”.
  • She shared the news on her podcast, MeSsy, saying the wrong diagnosis had once given her clarity, but now she is again searching for answers.
  • Applegate said she still uses a wheelchair for doctor visits and cannot walk from her car, while MS remains hard to diagnose and is often misdiagnosed, according to the Cleveland Clinic.

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LOS ANGELES - Actress Christina Applegate on Oct 20 said she had been misdiagnosed with multiple sclerosis, which doctors had attributed her symptoms to since 2021.

The Emmy-nominated actress, who first gained fame in the late 1980s for her role in the sitcom Married... with Children, said she continues to suffer debilitating symptoms and that learning of her misdiagnosis has only left her “back at square one”.

Applegate discussed the ordeal on the latest episode of her podcast, MeSsy.

“You don’t get misdiagnosed and then all of a sudden I’m better,” she told her co-host Jamie-Lynn Sigler of Sopranos fame, who herself has lived with multiple sclerosis for more than two decades.

Sigler had been hosting the podcast solo for months while Applegate dealt with health issues, including a lengthy hospital stay.

MS is an autoimmune neurodegenerative disease that affects nearly three million people worldwide and can be difficult to diagnose, leading to misdiagnoses in a fifth of cases, according to the Cleveland Clinic.

Applegate had previously described dealing with difficulty walking and balance problems, as well as a lack of coordination and numbness in her extremities.

But she said the diagnosis had provided some clarity and a path forward, whereas having no explanation for her symptoms left her once again searching.

“It’s hard to say, but she came into my room and she said, ‘Congratulations, you don’t have MS’,” Applegate said.

“I was like, not happy at all. Everybody else was so happy.”

“I still have to use wheelchairs when I go to the doctor’s office. I can’t walk from the car to the room. I’m still in this.” AFP

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