Manila probes 14 deaths amid dengue vaccine furore

A nurse displaying vials of Sanofi's dengue vaccine Dengvaxia, which has been recalled from local health centres in Manila, following the suspension of the country's public dengue immunisation programme.
A nurse displaying vials of Sanofi's dengue vaccine Dengvaxia, which has been recalled from local health centres in Manila, following the suspension of the country's public dengue immunisation programme.PHOTO: AFP

Philippines earlier stopped sale of drug after French maker warned of possible side-effects

MANILA • The Philippines is investigating if the deaths of 14 children had any link to a dengue vaccine whose use the government has suspended due to health concerns, officials said yesterday.

The country stopped the sale and distribution of Dengvaxia last month after Sanofi, the French manufacturer, warned it could worsen symptoms for people who had not previously been infected with the virus.

Sanofi has maintained the vaccine does not kill people, but did not comment on the health department's new announcement.

The government has assigned an independent panel of experts to review the cases and expects their findings in one or two weeks, Health Secretary Francisco Duque said.

"We asked them the question, first, what they think is the cause of death, and then second, do they think it is related to the vaccination," Assistant Health Secretary Enrique Domingo said.

More than 800,000 schoolchildren received the vaccine last year in the world's first public dengue immunisation programme.

Dengue was blamed for only four of the 14 deaths being probed, Mr Duque said, with lupus and meningococcemia named as the cause of the others. But now the panel of experts will verify those reports. "We need to watch out for 837,000 students who have been vaccinated and to us this is paramount," Mr Duque said.

He also said the government wants to return unused Dengvaxia stock worth 1.5 billion pesos (S$40 million) to Sanofi and get a refund.

  • 837,000

  • Number of schoolchildren who received the vaccine last year.

Last November, Sanofi released findings of a new study that said Dengvaxia could lead to severe infections for vaccinated people who caught dengue for the first time. It also urged the Philippine government not to suspend the vaccine's use, saying it was a crucial tool in fighting the deadly disease.

But the disclosure triggered a public furore, with some parents blaming the vaccine for their children's deaths and with a number of legislators accusing the health department of endangering public health.

In a move unrelated to yesterday's announcement, the department has suspended government clearance for Dengvaxia for one year and fined Sanofi 100,000 pesos. It ruled that Sanofi did not comply with Food and Drug Administration (FDA) regulations, a finding that the company has disputed.

The pharmaceutical giant said in a statement yesterday that it had complied with local regulations and FDA requirements. It added: "Sanofi Pasteur will continue to cooperate in full transparency with the Philippine FDA and is committed to comply with Philippine laws and regulations."

Dengue, a mosquito-borne illness, is a leading cause of serious illness and death among children in some Asian and Latin American countries, according to the World Health Organisation.

More than 1,000 people died of dengue last year in the Philippines, the health department said.

AGENCE FRANCE-PRESSE

A version of this article appeared in the print edition of The Straits Times on January 06, 2018, with the headline 'Manila probes 14 deaths amid dengue vaccine furore'. Print Edition | Subscribe