Tissue cells turned into skin cells to heal wounds

The research is the culmination of a decade of work and holds promise for a variety of patients.
The research is the culmination of a decade of work and holds promise for a variety of patients.PHOTO: ST FILE

TOKYO • In a world first, researchers have transformed tissue cells into skin cells to help heal serious wounds, a technique that could revolutionise care for victims of burns and other severe injuries.

The research is the culmination of a decade of work and holds promise for a variety of patients, including those with serious burns or elderly patients with bedsores and other recurring lesions.

The study, published yesterday in the journal Nature, involves a technology called "cell reprogramming" in which genes are inserted into cells to change them from one form to another.

"This is the first description of reprogramming of tissue cells to skin cells," lead author Masakazu Kurita told AFP. "I'm really excited about the results."

Professor Kurita, a plastic surgeon at the University of Tokyo, began working on the technique 10 years ago. The first stage involved identifying genes present in skin cells but not in tissue cells, which could be isolated and then inserted into tissue cells to transform them.

"We picked around 80 candidate genes featured in skin cells, then we tried combinations," Prof Kurita said.

His breakthrough came in 2014, when he successfully reprogrammed tissue cells into skin cells in a culture dish using a combination of 28 genes.

In 2015, he moved to the Salk Institute for Biological Studies in California to collaborate with a team of specialists from around the world.

In all, he and his colleagues conducted around 2,000 trials with different combinations of genes, looking for the most efficient way to transform cells.

Eventually, they hit upon a four-gene combination and began testing it in wounds on mice. They sealed the wounds off from the surrounding skin to replicate the difficult conditions at the centre of a large burn or similar injury, with no adjacent skin to promote healing.

Using the technology, along with existing drug treatments, they were able to heal a lesion 1cm in diameter in around two weeks.

"Our data suggests the feasibility of a completely new therapy which could be used for the closure of wounds from various causes," Prof Kurita said.

The most obvious application would be severe burns covering large parts of the body, which are usually treated with skin grafts, he added.

But he cautioned that the research was still far from being available to patients, with perhaps another decade of work needed before then.


A version of this article appeared in the print edition of The Straits Times on September 07, 2018, with the headline 'Tissue cells turned into skin cells to heal wounds'. Print Edition | Subscribe