Australia cancels local Covid-19 vaccine development due to HIV false positives

CSL has agreed to make another 20 million doses of AstraZeneca and Oxford University's vaccine. PHOTO: REUTERS

SYDNEY (REUTERS)- Australia cancelled the production of a locally made vaccine against Covid-19 after trials showed it could interfere with HIV diagnosis, the developers said, with the government instead securing additional doses of rival vaccines.

Antibodies generated by the vaccine being developed by the University of Queensland (UQ) and biotech firm CSL, one of four candidates contracted by the Australian government, were found to lead to some false positive HIV test results, the makers said.

While the vaccine had elicited a "robust" immune response to the novel SARS-COV-2 virus without serious adverse effects in a Phase 1 trial with 216 participants, re-engineering a fix could take another 12 months, they said. CSL and the Australian government had together decided to stop Phase 2 and Phase 3 trials.

"While this is a tough decision to take, the urgent need for a vaccine has to be everyone's priority," said UQ professor Paul Young.

The Australian vaccine could be re-engineered but doing so would take another 12 months.

"While this is a tough decision to take, the urgent need for a vaccine has to be everyone's priority," said Paul Young a UQ professor that co-lead the vaccine project.

CSL, which had a contract to produce 51 million doses of the UQ vaccine, will instead produce an extra 20 million doses of the Oxford vaccine being developed with Britain's AstraZeneca , taking the total to 53 million.

The government said it has also secured additional doses of Novavax vaccines. Australia also has a contract for 10 million doses of a vaccine being developed by Pfizer, with regulatory approval expected by January 2021.

JPMorgan analysts said the cancellation of the CSL contract removed an "important" opportunity for the vaccine maker that would have brought it A$100 million (S$101 million) in extra revenues. CSL shares fell 3.2 per cent on Friday, underperforming a slightly weaker broader market.

Vaccine roll-out

All up, Australia has secured 140 million vaccine units to inoculate its 25 million people, one of the highest ratios of vaccine purchases to population in the world, officials said.

The cancellation was announced before Prime Minister Scott Morrison's final meeting this year with state and territory leaders in Canberra - their first in-person meeting in nine months - to plan the vaccination roll-out and to develop seasonal visas for skilled workers and students.

"We want to ensure that Australians ... have full confidence, absolute full confidence that when it gets the tick, they can get the jab, and they can make that decision for themselves and for their families, confidently," Mr Morrison told reporters.

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Despite suffering significant economic hits due to Covid-19, Australian consumer sentiment is climbing again as the country re-emerges from the pandemic faster than most.

Australia's tally of 28,000 Covid-19 infections is far fewer than in many other developed countries, and with only sporadic cases of the virus now showing up, it has not raced to start vaccinations as in North America and parts of Europe.

The country is scheduled to start vaccinations in March 2021 and expects to inoculate its whole population by the end of the year.

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