Fertility researchers use skin cells to create human sperm

BARCELONA • Scientists in Spain say they have created human sperm from skin cells, a medical feat which could eventually lead to a treatment for infertility.

The researchers said on Wednesday that they were working to find a solution for the roughly 15 per cent of couples worldwide who are unable to have children and whose only option is to use donated sperm or eggs.

"What to do when someone who wants to have a child lacks gametes (eggs or sperm)?" asked Dr Carlos Simon, the scientific director of the Valencian Infertility Institute, Spain's first medical institution fully dedicated to assisted reproduction.

"This is the problem we want to address: to be able to create gametes in people who do not have them."

The result of the research, which was undertaken with Stanford University in the United States, was published on Tuesday in Scientific Reports, the online journal of Nature.

The researchers were inspired by the work of Japan's Shinya Yamanaka and Britain's John Gurdon, who in 2012 shared the Nobel Prize in medicine for discovering that adult cells can be transformed back into embryo-like stem cells.

Dr Simon and his team managed to reprogramme mature skin cells by introducing a cocktail of genes needed to create gametes.

Within a month the skin cell was transformed to become a germ cell, which can develop into sperm or an egg, but it did not have the ability to fertilise, they found.

"This is a sperm but it needs a further maturation phase to become a gamete. This is just the beginning," Dr Simon said.

It is a step further than that reached by Chinese researchers, who earlier this year announced they had created mice from artificial sperm.

"With the human species, we must do much more testing because we are talking about the birth of a child," Dr Simon said.

The researchers also must take into account legal constraints since the technique involves the creation of artificial embryos, which is allowed only in some countries.

"We are talking about a long process," he said.

AGENCE FRANCE-PRESSE

A version of this article appeared in the print edition of The Straits Times on April 29, 2016, with the headline 'Fertility researchers use skin cells to create human sperm'. Print Edition | Subscribe