Criminal syndicates have links deep in the forests of Asia, Africa and Latin America, with wildlife trade routes leading to China and East Asia where the big markets lie - China for ivory, rosewood and other wildlife and timber products; and Vietnam for timber and rhino horn among others.
The rich tropical jungles of Southeast Asia are only one area being looted by environmental criminals.
Globally, over the past 10 years, over 1,000 park rangers have been killed, 80 per cent of them by commercial poachers and armed militia groups.
According to the Britain-based Global Witness, over 1,000 environmental and land rights activists and protesters have been murdered worldwide since 2002.
Between 2010 and 2012, 100,000 African elephants were killed out of a population of fewer than 500,000. Close to 100 African elephants are killed every day for their ivory - one every 15 minutes.
Chimpanzees, killed for meat and for the exotic pet trade, are now completely extinct in Gambia, Burkina Faso, Benin and Togo, where they were once numerous.
The harmless pangolin has been killed at the rate of an estimated 117,000 to 233,000 from 2011-2013.
Pangolin processing factories have been found deep in the jungles of Indonesia, and trucks stuffed with tonnes of pangolins have been found trying to cross from Malaysia to Thailand on the way to Laos and China. The UN has called for "zero tolerance for wildlife crime".
There are, however, some encouraging signs, says Bangkok-based regional coordinator Giovanni Broussard of UNODC's programme on combating wildlife and forest crime.
"The perception at least is that there is more awareness of the problem here in the region," he said.
"Asean ministers of public security last year agreed to list wildlife and timber trafficking as a priority area under transnational organised crime, and are establishing a working group. So the gravity of the situation is beginning to be appreciated."
In its first report on crime, released in May, the UNODC noted that "the trafficking of wildlife is increasingly recognised as both a specialised area of organised crime and a significant threat to many plant and animal species".
Analysts and activists say seizing contraband wildlife and timber is not enough; it must be followed by wide-ranging investigations of the sort that are brought to bear on terrorism and drug trafficking cases.
In one such case, the Thai authorities are prosecuting a woman in the north central province of Chaiyaphum, who ran a tiger farm - and whose brother was caught poaching rosewood.
The authorities confiscated millions of dollars worth of assets from them, said Mr Tim Redford of the Freeland Foundation in Bangkok, which trains Thai rangers in the fight against poachers.
Halfway across the world, in Tanzania, a prominent Beijing-born Chinese businesswoman, Yang Fenglan, 66, is on trial, accused of leading one of Africa's biggest ivory smuggling rings, responsible for more than 700 elephant tusks worth US$2.5 million illegally shipped out of Tanzania. She denies the charges.
In his message to mark World Environment Day, which is observed annually on June 5, UN Secretary-General Ban Ki Moon said this year's observance "shines a much-needed spotlight on the illegal trade in wildlife".
"There is grave cause for alarm. Elephants are being slaughtered for their ivory, rhinos for their horns, and pangolins for their scales. From sea turtles to tigers to rosewood, thousands of species of wild animals and plants are being driven ever closer to extinction," he said.