Paris (AFP) - There is all to play for in an intriguing Group G. Spain are top on goal difference from Italy. But Israel are very much in the hunt, just one point behind.
Only the top team from each group is guaranteed a place in 2018 Russia with most of the teams finishing second going into play-offs.
That means either Spain or Italy - both former World Cup winners - are going to have to do it the hard way.
On Friday, Italy will fully expect to brush aside Albania. The same evening, Spain will need to be wary of Israel. His side might be the underdogs, but Israel boss Elisha Levy has vowed to go on the attack in Gijon.
The top-two clash in Group I when leaders Croatia entertain Ukraine on Friday in Zagreb.
Something needs to give: both are unbeaten after four games and victory for Croatia would give them a comfortable buffer in a group that also includes Euro 2016 surprise package Iceland and Turkey, third and fourth respectively.
Turkey's campaign has been a disappointment so far and they must beat Finland at home to keep any hopes of 2018 Russia alive. Iceland travel to the bottom side Kosovo.