Singapore's 2018 World Cup qualifier against Japan on June 16, originally scheduled as a home game, will now be an away match for the Lions.
The reverse fixture will take place on Nov 12 in Singapore.
The move paves the way for the match to be held at the National Stadium. The 55,000-seat venue hosts the closing ceremony of the SEA Games, also on June 16, meaning the match would likely have been played at the 8,000-capacity Jalan Besar Stadium.
The Football Association of Singapore said on Friday that the Japan Football Association, Asian Football Confederation and world governing body Fifa had agreed to this switch.
FAS president Zainudin Nordin said: "We look forward to hosting Japan on 12 November. It will be a major treat for all Singapore and Japan fans, and we are confident it will draw a strong crowd."
Besides Japan, Singapore are drawn alongside Cambodia, Afghanistan and Syria in Group E. The Lions open their campaign with an away match against Cambodia on June 11.