Prime Minister Lee Hsien Loong will meet United States President Barack Obama on a four day trip to Washington, DC and New York City that begins on Monday.
This will be PM Lee's first meeting with Mr Obama in the White House and his first official trip to the US since July 2010.
During the visit, Mr Lee will also meet with Secretary of State John Kerry, Treasury Secretary Jacob Lew, Secretary of Defence Charles Hagel and World Bank Group President Jim Yong Kim, said a statement from the Prime Minister's Office on Thursday.
In New York City, he will meet Mayor Michael Bloomberg, former US Secretary of State Hillary Clinton and several business leaders.
Mr Lee will be accompanied by Minister for Trade and Industry Lim Hng Kiang, Minister for Foreign Affairs K. Shanmugam and MPs Dr Intan Azura (Ang Mo Kio GRC) and Mr Desmond Lee (Jurong GRC).
The White House said in a statement on Wednesday that the meeting would focus on a range of strategic and economic questions in the Asia Pacific region.
"The prime minister's visit underscores the strategic importance the president places on Asia and the value we place on our relationship with Singapore as a key partner," said the statement from the White House.
During Mr Lee's absence, Deputy Prime Minister Mr Teo Chee Hean will be the Acting Prime Minister.