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Singapore researchers find new antibiotic mixes to fight superbugs

Singapore researchers hope to test 3 formulas on animals within a year

Published on Aug 23, 2014 7:44 AM
 
Posed photo. Researchers in Singapore have come up with a way to fight superbug infections by combining antibiotics into more effective cocktails. -- PHOTO: ST FILE

Researchers in Singapore have come up with a way to fight superbug infections by combining antibiotics into more effective cocktails.

They have developed three antibiotic combinations to not only kill the drug-resistant bacteria but also slow down its mutation to become resistant.

The different antibiotic types in each combination complement one another by fighting bacteria in different ways, for instance by destroying bacterial cell walls.

Laboratory tests showed the three-drug combos killed even multi-drug resistant bacteria strains like Pseudomonas aeruginosa and Klebsiella pneumoniae, and were more potent than any single drug alone.

 
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Background story

LAST LINE OF DEFENCE

This anchor drug is used against resistant bacteria as a last line of defence but is especially toxic. By combining it with other antibiotics, we are able to lower the toxic dose, achieve higher kill rates against resistant bacteria and extend the lifespan of this valuable drug.

- Dr Desmond Heng, on one drug being used in all three combinations

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