Study hints at brain chemistry of cocaine withdrawal pain
Published on Sep 11, 2012 6:16 AM
WASHINGTON (AFP) - United States (US) researchers have uncovered part of what's happening, on a cellular level, to make cocaine addicts going cold turkey feel so bloody awful, according to a study published on Monday.
The results provide a better understanding of what's creating that crashing low of withdrawal - and may offer a clue for researchers looking to mitigate the symptoms and keep the user from relapsing.
Studying genetically-engineered mice, the researchers focused on a molecule - called cannabinoid receptor 1, or CB1 - that slows communication between nerve cells.
The molecule is particularly important in what is called the nucleus accumbens region of the brain, which governs emotion and motivation.
To continue reading, log in if you are a subscriber
If you are not a subscriber, you can get instant, unlimited access here