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Study finds why antidepressants work better for some

Published on Sep 19, 2012 9:37 PM

LONDON (REUTERS) - British scientists have identified biological markers in the blood which should help doctors match patients to the best type of treatment for depression.

The aim is to end the "trial and error" prescription of antidepressants, which is often the only way depressed patients can find the most effective treatment, said researchers regarding what they described as a small but promising study.

"The study shows that we could use a blood-based "test" to personalise the treatment of depression," said Ms Carmine Pariante of King's College London's Institute of Psychiatry, who led the study.

She and colleagues found that high levels of inflammation - which show up in biological markers in the blood - are part of the mechanism leading to depression, especially to particular forms of the condition that do not respond well to mild or low-dose antidepressants.

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