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Pfizer breast cancer drug delays progression by 18 months

Published on Dec 6, 2012 5:58 AM
 
A sign for pharmaceutical company Pfizer Inc headquarters is displayed on 42 Street in New York in October 2009. Pfizer's experimental drug showed impressive effectiveness and safety in a mid-stage trial against a common form of advanced breast cancer. The drug, called PD-0332991, delayed by more than 18 months the worsening of symptoms for postmenopausal women with the most common form of breast cancer. -- PHOTO: AFP

(REUTERS) - An experimental drug showed impressive effectiveness and safety in a mid-stage trial against a common form of advanced breast cancer, lifting Pfizer Inc shares nearly 2 per cent.

The favourable results prompted the drugmaker to plan large late-stage trials of the drug next year. If approved, the medicine could fetch multi-billion dollar sales, industry analysts said.

The drug, called PD-0332991, delayed by more than 18 months the worsening of symptoms for postmenopausal women with the most common form of breast cancer. Data from the study of the drug was presented on Dec 5 at the annual San Antonio Breast Cancer Symposium.

The medicine, which blocks enzymes known as CDK4 and 6 kinases, was taken in combination with a standard drug called letrozole among women who were estrogen receptor positive - meaning tumours grow in response to estrogen - and HER2-negative, meaning that the HER2 protein is not causing the cancer. Such patients make up about 60 per cent of breast cancer cases.

 
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