A striker in disguise? Cristiano Ronaldo has had 96 efforts on target this season and with 27 goals he is the Premier League's leading marksman. Add his dribbling skills, and Arsenal left-back Gael Clichy will have his hands full.
Having already slammed his teammates' sloppy defending against Liverpool in the Champions League quarter-final as 'ridiculous', Clichy has to make sure his words do not return to bite him.
Wayne Rooney v Kolo Toure
Arsenal fans will not forget Wayne Rooney's League debut when, as a 16-year-old Evertonian, he ended the Gunners' 30-match unbeaten run in 2002 with a scorcher.
Since then, Ronney has scored five times against the Gunners.
Kolo Toure's season has been a topsy-turvy one, interrupted by injury, the African Cup of Nations and conceding the penalty that sent Liverpool, instead of his side, to the Champions League semi-finals.
He cannot afford another mistake, with Arsenal's season on the line.
Wes Brown v Emmanuel Adebayor
While Rio Ferdinand should continue to play in the defence for United despite stitches in his foot, the side will have to cope without Nemanja Vidic.
When Wes Brown was moved to central defence against Middlesbrough last week, United conceded twice. He remains a liability.
Arsenal striker Emmanuel Adebayor is without a League goal since Feb 11, but if he can take advantage of Brown's unsteady presence at the back, he may just end that unwanted streak.
He struck the winner at Old Trafford in the corresponding Premier League fixture last term.