Felipe Massa (1 min, 44.801 sec), Lewis Hamilton (1:45.465) and Kimi Raikkonen (1:45.617) will head the pack after setting the fastest times in the qualifying session last night.
'I'm looking forward to a good job tomorrow,' said Ferrari's Massa, who notched his fifth pole position this season.
'If we can win the race, it'll be an even more fantastic feeling than qualifying.'
With drivers saying overtaking opportunities will be very limited around the twisty 5.067km Marina Bay circuit, Massa will be odds-on favourite to take the chequered flag after 61 laps.
Of his five wins this year - in Bahrain, Turkey, France, Valencia and Belgium - the Valencia and Turkish victories came when he started from pole.
Another win today for the Brazilian, who trails Hamilton by just one point in the drivers' standings, could go a long way to determining who wins the title.
The race winner gets 10 points, second-placed driver eight and third six.
Do not expect the aggressive Hamilton of McLaren to roll over easily though, with only three races left after the Singapore leg.
Said the Briton: 'I'll just play it by ear and give it my best shot. It's a tough race but the position we are in is quite good.'
The driver, who is into only his second year in F1, had insisted two weeks ago that he 'morally deserves' to win the championship, and will no doubt be going all out for a good start and attempt to overtake Massa at Turn 1.
Ferrari's Massa, seen by some as the long-term successor to his teammate and last year's champion Raikkonen at the Italian outfit, will need to keep his focus.
The challenging circuit's 23 turns are eight more than the average F1 track.
Said Massa: 'It will be a difficult race; concentration will be 10 times more than at a normal circuit.'
Providing another challenge will be the bumpy streets.
As Hamilton's teammate Heikki Kovalainen said: 'You go left, right, brake and accelerate in quick succession. Mentally, it's very tiring.'
Predictions of wet weather for the weekend, which could cause glare because of the artificial lighting, have so far not materialised when the cars have taken to the track.
But if it does pour, rain-master Hamilton, who won this year's British Grand Prix and last year's race in Japan in treacherous conditions, will fancy his chances.
Earlier yesterday, Fernando Alonso set the fastest time in the third and final practice before qualifying.
His Renault, however, stalled in the second qualifying session and he will start from 15th on today's grid.
For the second day in a row, Singaporeans and overseas visitors packed the Marina area, with about 70,000 pairs of eyes trained on the roaring machines.
A capacity crowd of 100,000 fans is expected to flood the city centre again today for the country's biggest-ever sporting event.
There has also been keen interest among Singapore's leadership.
Among those catching the action yesterday were President SR Nathan and Defence Minister Teo Chee Hean.
More members of the Cabinet are expected to witness the crowning of the inaugural night race champion today.
Said Mr Colin Syn, deputy chairman of race organiser Singapore GP: 'I feel very proud; this is really good for Singapore. I'm looking forward to tomorrow.'
